Genetic syndrome may have links to Parkinson's disease - 21 News Now, More Local News for Youngstown, Ohio -

Genetic syndrome may have links to Parkinson's disease

Updated:
© iStockphoto.com / Ryan Pike © iStockphoto.com / Ryan Pike

MONDAY, Sept. 9 (HealthDay News) -- A genetic deletion may be linked to some cases of early onset Parkinson's disease, researchers say.

The investigators found that people aged 35 to 64 who were missing DNA on a specific part of chromosome 22 were about 90 times more likely to develop Parkinson's than people from the same age group in the general population.

People with this inherited genetic condition -- called 22q11.2 deletion syndrome -- have about 50 genes missing on chromosome 22. The condition occurs in about one in 2,000 to 4,000 people, and those with this genetic deletion may have birth defects (including heart defects), learning or speech difficulties, anxiety disorders, or schizophrenia.

Previously reported cases of patients with 22q11.2 deletion syndrome and Parkinson's disease symptoms have indicated that there may be a link between the two conditions, according to the researchers from the Center for Addiction and Mental Health and University Health Network in Toronto.

Dr. Anne Bassett, director of the Center for Addiction and Mental Health's Clinical Genetics Research Program, said 22q11.2 deletion syndromes has been studied in children and adolescents, but less is known about the syndrome in adults.

In addition, in some cases, Parkinson's disease in 22q11.2 deletion syndrome is associated with abnormal accumulations of a type of protein in the brain (called Lewy bodies), similar to what has been found in another genetic form of Parkinson's, the study authors said.

The findings, published online Sept. 9 in the journal JAMA Neurology, indicate that adults with 22q11.2 deletion syndrome should undergo routine checks for signs of Parkinson's disease.

"Most people with 22q11.2 [deletion syndrome] will not develop Parkinson's disease," Bassett, director of the University Health Network's Dalglish Family Hearts and Minds Clinic, the world's first clinic dedicated to adults with 22q11.2 deletion syndrome, said in a news release. "But it does occur at a rate higher than in the general population. We will now be on the lookout for this so we can provide the best care for patients."

Although the study found an association between 22q11.2 deletion syndrome and Parkinson's disease, it did not find a cause-and-effect relationship.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about Parkinson's disease.

Copyright © 2013 HealthDay. All rights reserved.

*DISCLAIMER*: The information contained in or provided through this site section is intended for general consumer understanding and education only and is not intended to be and is not a substitute for professional advice. Use of this site section and any information contained on or provided through this site section is at your own risk and any information contained on or provided through this site section is provided on an "as is" basis without any representations or warranties.
  • More From wfmj.comMore>>

  • 1 of 2 Ohio plane crash victims not yet identified

    1 of 2 Ohio plane crash victims not yet identified

    Monday, July 28 2014 9:48 PM EDT2014-07-29 01:48:43 GMT
    FINDLAY, Ohio (AP) - Authorities in northwest Ohio are still trying to identify one of two people killed in a weekend plane crash. One of the victims in the crash near Findlay was the CEO of an Ohio manufacturing company. A coroner was trying to identify the remains of a woman killed in the crash, but the Hancock County Sheriff's Office says DNA testing may be needed. Deputies say Ralf Bronnenmeier, CEO of Grob Systems in Bluffton, was piloting the single-engine plane that crashed early Sund...More >>
    FINDLAY, Ohio (AP) - Authorities in northwest Ohio are still trying to identify one of two people killed in a weekend plane crash. One of the victims in the crash near Findlay was the CEO of an Ohio manufacturing company. A coroner was trying to identify the remains of a woman killed in the crash, but the Hancock County Sheriff's Office says DNA testing may be needed. Deputies say Ralf Bronnenmeier, CEO of Grob Systems in Bluffton, was piloting the single-engine plane that crashed early Sund...More >>
  • TSA finds gun, ammo in Pittsburgh airport carry-on

    TSA finds gun, ammo in Pittsburgh airport carry-on

    Monday, July 28 2014 9:35 PM EDT2014-07-29 01:35:49 GMT
    IMPERIAL, Pa. (AP) - The Transportation Security Administration says it found a pistol and ammunition in man's carry-on bag as he passed through security at Pittsburgh International Airport. TSA official tell the Pittsburgh Tribune-Review that the man wasn't allowed take the gun past security, and faces up to a $11,000 civil penalty for bringing the weapon to the checkpoint. But Allegheny County police say they don't plan to charge the man with a crime because he had a license to carry the ....More >>
    IMPERIAL, Pa. (AP) - The Transportation Security Administration says it found a pistol and ammunition in man's carry-on bag as he passed through security at Pittsburgh International Airport. TSA official tell the Pittsburgh Tribune-Review that the man wasn't allowed take the gun past security, and faces up to a $11,000 civil penalty for bringing the weapon to the checkpoint. But Allegheny County police say they don't plan to charge the man with a crime because he had a license to carry the ....More >>
  • 5 Pa. reps ask NCAA to halt Penn State sanctions

    5 Pa. reps ask NCAA to halt Penn State sanctions

    Monday, July 28 2014 9:29 PM EDT2014-07-29 01:29:22 GMT
    Five Pennsylvania congressmen are asking college sports' governing body to cancel penalties against Penn State imposed as a result of the Jerry Sandusky child molestation scandal.More >>
    Five Pennsylvania congressmen are asking college sports' governing body to cancel penalties against Penn State imposed as a result of the Jerry Sandusky child molestation scandal.
    More >>
Powered by WorldNow
All content © Copyright 2000 - 2014 Worldnow and WFMJ. All Rights Reserved. For more information on this site, please read our Privacy Policy and Terms