Gene mutation helps predict lung cancer survival in nonsmokers - 21 News Now, More Local News for Youngstown, Ohio -

Gene mutation may help predict lung cancer survival in nonsmokers

Updated: Sep 12, 2013 01:28 PM
© Stockbyte / Thinkstock © Stockbyte / Thinkstock

THURSDAY, Sept. 12 (HealthDay News) -- Researchers say they've identified a gene mutation that's associated with a higher risk of lung cancer in women who do not smoke, but a better chance of survival in female and male lung cancer patients.

The mutation, which occurs in a gene that protects cells from oxidative stress, is found four times more often in women than in men, according to the study published Sept. 11 in the journal PLoS One.

The researchers analyzed the DNA of lung cancer patients in Japan and found that nonsmoking women with two copies of the -617A mutation in the NFR2 gene had a much higher incidence of lung cancer than nonsmoking men.

The investigators also found that both female and male lung cancer patients with this mutation had better survival rates than other patients.

This is the first study to provide clinical evidence that this mutation is associated with lung cancer patient survival, said researcher Dr. Toshihisa Ishikawa and colleagues at the RIKEN Center for Life Science Technologies in Japan.

The study strongly suggests that the presence of this mutation "is a good prognostic biomarker for the assessment of the overall survival chances of patients with adenocarcinoma, as well as a practical tool for personalized cancer therapy," Ishikawa said in a RIKEN news release.

Although the study found an association between the gene mutation and lung cancer survival, it did not prove a cause-and-effect relationship.

Lung cancer is the leading cause of cancer-related deaths in many industrialized countries, according to background information in the news release. Smoking is the main cause of lung cancer, but 10 percent to 15 percent of cases occur in nonsmokers.

More information

The U.S. National Cancer Institute has more about lung cancer.

Copyright © 2013 HealthDay. All rights reserved.

*DISCLAIMER*: The information contained in or provided through this site section is intended for general consumer understanding and education only and is not intended to be and is not a substitute for professional advice. Use of this site section and any information contained on or provided through this site section is at your own risk and any information contained on or provided through this site section is provided on an "as is" basis without any representations or warranties.
  • More From wfmj.comMore>>

  • $2M offered to Ohio farmers to help reduce algae

    $2M offered to Ohio farmers to help reduce algae

    Tuesday, August 19 2014 10:07 PM EDT2014-08-20 02:07:19 GMT
    TOLEDO, Ohio (AP) - The federal government is offering $2 million to Ohio farmers to help prevent farm runoff that contributes to potentially harmful algae blooms. Farmers in 20 counties in the western Lake Erie watershed can apply for some of the funds to plant cover crops to reduce nutrient runoff and erosion. The federal money, provided by the Natural Resources Conservation Service, is aimed at reducing future algae blooms. U.S. Sen. Sherrod Brown and Toledo Rep. Marcy Kaptur announced th...More >>
    TOLEDO, Ohio (AP) - The federal government is offering $2 million to Ohio farmers to help prevent farm runoff that contributes to potentially harmful algae blooms. Farmers in 20 counties in the western Lake Erie watershed can apply for some of the funds to plant cover crops to reduce nutrient runoff and erosion. The federal money, provided by the Natural Resources Conservation Service, is aimed at reducing future algae blooms. U.S. Sen. Sherrod Brown and Toledo Rep. Marcy Kaptur announced th...More >>
  • 5K-8K gallons of fuel oil spills into Ohio River

    5K-8K gallons of fuel oil spills into Ohio River

    Tuesday, August 19 2014 10:06 PM EDT2014-08-20 02:06:15 GMT
    CINCINNATI (AP) - An estimated 5,000 to 8,000 gallons of fuel oil spilled into the Ohio River, closing about a 15-mile section of the waterway southeast of Cincinnati. A Coast Guard spokeswoman says that the section of river was closed to river traffic Tuesday to enable cleanup and response. A Duke Energy spokeswoman says the spill from a Duke power plant in New Richmond, about 20 miles southeast of Cincinnati, happened late Monday night. Duke Energy spokeswoman Sally Thelen says the spill oc...More >>
    CINCINNATI (AP) - An estimated 5,000 to 8,000 gallons of fuel oil spilled into the Ohio River, closing about a 15-mile section of the waterway southeast of Cincinnati. A Coast Guard spokeswoman says that the section of river was closed to river traffic Tuesday to enable cleanup and response. A Duke Energy spokeswoman says the spill from a Duke power plant in New Richmond, about 20 miles southeast of Cincinnati, happened late Monday night. Duke Energy spokeswoman Sally Thelen says the spill oc...More >>
  • Couple stabbed at Ohio home; adult son charged

    Couple stabbed at Ohio home; adult son charged

    Tuesday, August 19 2014 10:03 PM EDT2014-08-20 02:03:06 GMT
    WESTLAKE, Ohio (AP) - A 22-year-old man suspected of stabbing his parents at their suburban Cleveland home has been charged with felonious assault. Westlake police said in a statement Tuesday that a 58-year-old man was flown to a Cleveland hospital with life-threatening injuries, and his 56-year-old wife was in stable condition. Police say authorities learned about the stabbings after a hang-up 911 call Monday night and a subsequent callback by a dispatcher. The couple's son was arrested wit...More >>
    WESTLAKE, Ohio (AP) - A 22-year-old man suspected of stabbing his parents at their suburban Cleveland home has been charged with felonious assault. Westlake police said in a statement Tuesday that a 58-year-old man was flown to a Cleveland hospital with life-threatening injuries, and his 56-year-old wife was in stable condition. Police say authorities learned about the stabbings after a hang-up 911 call Monday night and a subsequent callback by a dispatcher. The couple's son was arrested wit...More >>
Powered by WorldNow
All content © Copyright 2000 - 2014 Worldnow and WFMJ. All Rights Reserved. For more information on this site, please read our Privacy Policy and Terms