Covis Pharmaceuticals Announces Its New Expanded Dosage Options of LANOXIN® for Cardiac Patients With Mild-to-Moderate Heart Failure - 21 News Now, More Local News for Youngstown, Ohio -

Covis Pharmaceuticals Announces Its New Expanded Dosage Options of LANOXIN® for Cardiac Patients With Mild-to-Moderate Heart Failure

  • More NewsMore>>

  • BREAKING NEWS

    Hostage released at the Trumbull County Jail

    Hostage released at the Trumbull County Jail

    A five hour hostage situation at the Trumbull County jail ended with the safe release of a corrections guard taken hostage by 3 inmates.

    Authorities “talked it out” with the inmates resulting in the release of the guard who at one point had a homemade prison weapon held to his throat.
    More >>
    A five hour hostage situation at the Trumbull County jail ended with the safe release of a corrections guard taken hostage by 3 inmates.

    Authorities “talked it out” with the inmates resulting in the release of the guard who at one point had a homemade prison weapon held to his throat.
    More >>
  • Suspect in Trumbull County jail hostage crisis facing death penalty case

    Suspect in Trumbull County jail hostage crisis facing death penalty case

    Wednesday, April 23 2014 8:55 PM EDT2014-04-24 00:55:14 GMT
    One of the three inmates identified as being involved in a hostage situation at the Trumbull County jail faces criminal charges that could bring the death penalty if convicted.Authorities say that 29-year-old David Martin of Cleveland is awaiting trial for the murder of Jeremy Cole in Warren in October, 2012.Martin was a neighbor of Cole who was shot to death at a home on Oak Circle SW. A woman was also wounded during the crime.The Trumbull County Grand Jury handed up a ten count indictment a...More >>
    One of the three inmates identified as being involved in a hostage situation at the Trumbull County jail faces criminal charges that could bring the death penalty if convicted.Authorities say that 29-year-old David Martin of Cleveland is awaiting trial for the murder of Jeremy Cole in Warren in October, 2012.Martin was a neighbor of Cole who was shot to death at a home on Oak Circle SW. A woman was also wounded during the crime.The Trumbull County Grand Jury handed up a ten count indictment a...More >>
  • Remembering Idora Park over the years

    Remembering Idora Park over the years

    Wednesday, April 23 2014 8:52 PM EDT2014-04-24 00:52:10 GMT
    This Saturday will mark the 30th anniversary of the devastating fire that led to the closing of the Idora Amusement Park. Glenn Stevens took a look back at Idora Park's history and the memories it made for generations. More >>
    This Saturday will mark the 30th anniversary of the devastating fire that led to the closing of the Idora Amusement Park. Glenn Stevens took a look back at Idora Park's history and the memories it made for generations. More >>

Information contained on this page is provided by an independent third-party content provider. WorldNow and this Station make no warranties or representations in connection therewith. If you have any questions or comments about this page please contact pressreleases@worldnow.com.

SOURCE Covis Pharmaceuticals, Inc.

CARY, N.C., Feb. 7, 2014 /PRNewswire/ -- Covis Pharmaceuticals today announced that LANOXIN® is now offered in four dosage strengths, including the new 0.0625mg and 0.1875mg strengths, for the treatment of mild-to-moderate heart failure in adults, and for the control of ventricular response rate in adult patients with chronic atrial fibrillation. Current dosing options of 0.250mg and 0.125mg are still available. These four convenient strengths are currently stocked in all major wholesalers.

The 2013 American College of Cardiology Foundation/American Heart Association (ACCF/AHA) Guidelines now support maintaining a Serum Digoxin Concentration (SDC) in the range of 0.5 to 0.9ng/ml. Some patients may require lower LANOXIN® dosing to achieve the recommended target SDC levels.

In the Digitalis Investigation Group (DIG) study, LANOXIN® was associated with a reduction in hospitalizations, including a 25% reduction in risk for the number of heart failure hospitalizations, and a 6% reduction in number of hospitalizations for any cause, while having no effect on mortality.

LANOXIN® increases left ventricular ejection fraction and improves heart failure symptoms as evidenced by improved exercise capacity and decreased heart failure-related hospitalizations and emergency care, while having no effect on mortality. Where possible, LANOXIN® should be used in combination with a diuretic and an angiotensin-converting enzyme (ACE) inhibitor. It is a registered trademark of the GlaxoSmithKline group of companies.

Important Safety Information
CONTRAINDICATIONS: LANOXIN is contraindicated in patients with ventricular fibrillation and in patients with a known hypersensitivity to digoxin or other forms of digitalis. WARNINGS AND PRECAUTIONS: Patients taking digoxin who have atrioventricular (AV) accessory pathway like Wolff-Parkinson-White syndrome are at risk of ventricular fibrillation. Treatment in these patients with digoxin leads to greater slowing of AV node conduction and increases the risk of rapid ventricular response leading to ventricular fibrillation.

Patients with sinus node disease are at risk for severe sinus bradycardia or sinoatrial block. Patients with incomplete AV block are at risk for advanced or complete heart block.

There is a risk of toxicity when taking LANOXIN. Toxicity is usually associated with digoxin levels >2.0ng/mL, although symptoms may also occur at lower levels. Signs and symptoms of digoxin toxicity include anorexia, nausea, vomiting, visual changes and cardiac arrhythmias.  Low body weight, advanced age, impaired renal function and electrolyte abnormalities increase a patient's risk of toxicity. Select the LANOXIN dosage carefully and adjust as the clinical condition of the patient warrants. Measure digoxin levels when signs and symptoms of toxicity are present and adjust the dose or discontinue as necessary.

Patients on digoxin receiving electrical cardioversion are at risk for ventricular arrhythmias. It may be desirable to reduce the dose of, or discontinue, LANOXIN for 1 to 2 days prior to electrical cardioversion of atrial fibrillation to avoid induction of ventricular arrhythmias, but physicians must consider the consequences of all options. If digitalis toxicity is suspected, elective cardioversion should be delayed.

LANOXIN is not recommended in patients with acute myocardial infarction as digoxin may increase myocardial oxygen demand and lead to ischemia. LANOXIN should not be used in patients with myocarditis as it can precipitate vasoconstriction and may promote production of pro-inflammatory cytokines.

Patients with certain disorders involving heart failure associated with preserved left ventricular ejection fraction may experience decreased cardiac output. Such disorders include restrictive cardiomyopathy, constrictive pericarditis, amyloid heart disease, and acute cor pulmonale.

Patients with idiopathic hypertrophic subaortic stenosis may have worsening of the outflow obstruction due to inotropic effects of digoxin. Patients with amyloid heart disease may be at higher risk of digoxin toxicity. Digoxin should generally be avoided in these patients.

Hypocalcemia may reduce digoxin requirements. These interactions are because digoxin can affect contractility and excitability of the heart in a manner similar to that of calcium.

Patients with hypothyroidism may require less digoxin. In patients with heart failure and/or atrial arrhythmias resulting from hypermetabolic or hyperdynamic states (e.g., hypothyroidism, hypoxia, or arteriovenous shunt) the underlying condition should be treated. Atrial arrhythmias associated with hypermetabolic states are particularly resistant to digoxin treatment. Patients with beri beri heart disease may fail to respond adequately to digoxin if the underlying thiamine deficiency is not treated concomitantly.

ADVERSE REACTIONS: In a large clinical trial, the incidence of hospitalization for suspected digoxin toxicity was 2% in patients taking LANOXIN compared to 0.9% in patients taking placebo. The overall incidence of adverse reactions with digoxin has been reported as 5-20%, with 15-20% of adverse events considered serious. Cardiac toxicity accounts for about one-half, gastrointestinal disturbances for about one-fourth, and CNS and other toxicity for about one-fourth of these adverse events. In general, the adverse reactions of LANOXIN are dose- dependent and occur at doses higher than those needed to achieve a therapeutic effect.

DRUG INTERACTIONS: Digoxin has a narrow therapeutic index; increased monitoring of serum digoxin concentration is necessary when initiating, adjusting or discontinuing drugs that may interact with digoxin. Prescribers should consult the prescribing information for further information on any potential drug interactions with digoxin.

Full Prescribing Information
Full prescribing information can be found here: http://www.covispharma.com/pdfs/lanoxin-tablets-pi.pdf

About Covis Pharmaceuticals
Covis Pharmaceuticals is a specialty pharmaceutical distributor dedicated to improving the lives of people with life-threatening conditions and chronic illnesses. It is our mission to provide our customers with a continuous supply of safe, efficacious, and affordable therapeutic solutions.

Covis Pharma, Sarl, a Switzerland-based specialty pharmaceutical company is a supplier of Covis Pharmaceuticals.

©2012 PR Newswire. All Rights Reserved.

  • More From wfmj.comMore>>

  • Restaurant plans new statue of Joe Paterno

    Restaurant plans new statue of Joe Paterno

    Wednesday, April 23 2014 12:57 PM EDT2014-04-23 16:57:56 GMT
     (AP) - Fans of the late Penn State University football coach Joe Paterno are planning to commission a new bronze statue of him, and place it across from the school. Organizers say the statue will feature Paterno sitting on a bench reading. It's expected to cost about $300,000 and would hopefully be done in 2015 by Philadelphia sculptor Zenos Frudakis. Penn State spokeswoman Lisa Powers says the school isn't involved in the plan. But a restaurant owner in downtown State Col...More >>
     (AP) - Fans of the late Penn State University football coach Joe Paterno are planning to commission a new bronze statue of him, and place it across from the school. Organizers say the statue will feature Paterno sitting on a bench reading. It's expected to cost about $300,000 and would hopefully be done in 2015 by Philadelphia sculptor Zenos Frudakis. Penn State spokeswoman Lisa Powers says the school isn't involved in the plan. But a restaurant owner in downtown State Col...More >>
  • Woman allegedly sold heroin from hospital bed

    Woman allegedly sold heroin from hospital bed

    Wednesday, April 23 2014 11:01 AM EDT2014-04-23 15:01:45 GMT
    A woman in western Pennsylvania is accused of selling heroin from a hospital intensive care unit and a hospital room.More >>
    A woman in western Pennsylvania is accused of selling heroin from a hospital intensive care unit and a hospital room.More >>
  • Jet stowaway undetected for hours before departure

    Jet stowaway undetected for hours before departure

    Tuesday, April 22 2014 11:44 PM EDT2014-04-23 03:44:25 GMT
    Surveillance cameras at San Jose International Airport successfully captured the teenager on the tarmac, climbing up the landing gear of a jet. But in the end, the cameras failed because no one noticed the security...More >>
    A 15-year-old stowaway who survived a flight over the Pacific in a jet's wheel well spent seven hours undetected in what is supposed to be a highly secure area of San Jose International Airport before the flight...More >>
  • Hot ClicksHot ClicksMore>>

  • Can an app save the planet?

    Can an app save the planet?

    This startup's Earth Day launch has a massive goal: Cut carbon emissions globally. It has its work cut out for it.
    More >>
    This startup's Earth Day launch has a massive goal: Cut carbon emissions globally. It has its work cut out for it.
    More >>
  • 'Captain America' holds onto top box office spot

    'Captain America' holds onto top box office spot

    Monday, April 21 2014 10:47 PM EDT2014-04-22 02:47:39 GMT
    LOS ANGELES (AP) - Captain America really is unbeatable - at least at the box office"Captain America: The Winter Soldier" has been the top draw at theaters for three consecutive weeks, vanquishing would-be foes including the new thriller starring Johnny Depp.According to Monday's final box office figures, the Marvel sequel added $25.6 million in ticket sales over the weekend. "The Winter Soldier" has made more than $200 million domestically since logging the best April opening in history."Hea...More >>
    LOS ANGELES (AP) - Captain America really is unbeatable - at least at the box office"Captain America: The Winter Soldier" has been the top draw at theaters for three consecutive weeks, vanquishing would-be foes including the new thriller starring Johnny Depp.According to Monday's final box office figures, the Marvel sequel added $25.6 million in ticket sales over the weekend. "The Winter Soldier" has made more than $200 million domestically since logging the best April opening in history."Hea...More >>
  • Netflix poised to raise prices after strong 1Q

    Netflix poised to raise prices after strong 1Q

    Monday, April 21 2014 10:37 PM EDT2014-04-22 02:37:26 GMT
    SAN FRANCISCO (AP) - Netflix is preparing a sequel unlikely to be a hit with its subscribers. The Internet video service is about to raise its prices for the first time in three years to help pay for more Internet video programming such as its popular political drama "House of Cards."The increase, to take place sometime before July, will hike prices by $1 or $2 per month for new customers. The company's nearly 36 million current subscribers will continue to pay $8 per month for at least the n...More >>
    SAN FRANCISCO (AP) - Netflix is preparing a sequel unlikely to be a hit with its subscribers. The Internet video service is about to raise its prices for the first time in three years to help pay for more Internet video programming such as its popular political drama "House of Cards."The increase, to take place sometime before July, will hike prices by $1 or $2 per month for new customers. The company's nearly 36 million current subscribers will continue to pay $8 per month for at least the n...More >>
Powered by WorldNow
All content © Copyright 2000 - 2014 Worldnow and WFMJ. All Rights Reserved. For more information on this site, please read our Privacy Policy and Terms