Part of the eastbound lanes of U.S. Route 422 was closed for a time Wednesday morning following a crash.
Witnesses told dispatchers that a vehicle flipped over onto its side along the highway just west of Route 305 shortly before 7:30 a.m.
Bystanders worked to rescue a woman who was trapped inside the vehicle.
A rescue squad transported two people to St. Joseph Hospital. State Troopers had no information about the condition of the victims.
One lane of eastbound 422 was open within a half hour.
The patrol is still investigating.