Multiple departments were called to a home in Negley Friday afternoon.
Crews from East Palestine, Middleton Township and Columbiana Fire Departments arrived to find the home in the 6900 block of Adams Road in flames around 2:06 p.m.
Officials said the family was not home at the time and arrived after the blaze was put out.
Most of the home burnt down and is a total loss.
There's no word on what led to the fire at this point.