CLEVELAND, Ohio - Closing arguments are scheduled to begin Monday in a trial that started six weeks ago over claims by Ohio’s Trumbull and Lake Counties against major pharmacy chains over allegations that they contributed to the nation’s opioid crisis.

The case, which could set the tone for similar lawsuits against retail pharmacy chains by government entities across the U.S., is being heard in U.S. District Court in Cleveland.

Walgreens, CVS, and Walmart are the remaining defendants in the case. Giant Eagle and Rite-Aid have reached settlements with the counties.

The lawsuit alleges that the way pharmacies dispensed pain pills contributed to the opioid crisis and constituted a public nuisance in their communities.

The counties claim that between 2000 and 2014, the pharmacies dispensed 68-million doses of opioids in Trumbull County. With a population of 209,000, attorneys say that is the equivalent of 320 pills for every resident during the period.

Attorneys for the pharmacies claim that they followed legal requirements while filling prescriptions.