At least one eastbound lane of Interstate 80 is back open in Mercer County after a multi-vehicle crash Wednesday afternoon.  

The highway is closed from the on-ramp at the I-80 Welcome Center near the Ohio state border to Exit 4A (Interstate 376 East, New Castle).

The roadway is expected to fully reopen later. 

This is a developing story. Stay connected with 21 News on-air and online as more information becomes available.